Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
about
Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysisGranzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicksHMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme ACleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme AA quarter century of granzymesHepatitis B and Hepatitis C Virus Replication Upregulates Serine Protease Inhibitor Kazal, Resulting in Cellular Resistance to Serine Protease-Dependent ApoptosisStructure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesGranzyme A: the road less traveledGranzyme M mediates a novel form of perforin-dependent cell deathCell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity.Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection.Granzyme A activates another way to dieDelivery and therapeutic potential of human granzyme B.Death by a thousand cuts: granzyme pathways of programmed cell deathGranzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo.Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells.Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.Granzymes drive a rapid listeriolysin O-induced T cell apoptosisDifferential expression of granzyme B and C in murine cytotoxic lymphocytes.The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.A proteomic approach for the discovery of protease substrates.The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease.Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.Granzymes and caspase 3 play important roles in control of gammaherpesvirus latencySuperantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells.Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A.Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.Hop cleavage and function in granzyme B-induced apoptosis.Serpins prevent granzyme-induced death in a species-specific manner.Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity.SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease.
P2860
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P2860
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@en
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@nl
type
label
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@en
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@nl
prefLabel
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@en
Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
@nl
P2093
P1433
P1476
Granzyme A initiates an alternative pathway for granule-mediated apoptosis
@en
P2093
P304
P356
10.1016/S1074-7613(00)80059-X
P407
P577
1999-05-01T00:00:00Z