about
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinDiscovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis.Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse.M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's locationModulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.Modulation of excitatory synaptic transmission by endogenous glutamate acting on presynaptic group II mGluRs in rat substantia nigra compacta.mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons.Activity-dependent bidirectional modification of inhibitory synaptic transmission in rat subthalamic neurons.Biased M1 receptor-positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticitymGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling
P50
Q24647634-9D22FCA0-8C75-43C7-8952-684ACC21AF90Q28260708-418DEE44-F344-4517-BD36-849F80936B71Q30402875-EA23AA40-56EC-4C20-87AB-D0741AC18251Q30427775-29A7400A-3312-4D20-ACAC-11599FCA88BBQ30474039-27B1EB81-8FC4-4E13-B5C6-59380253DC14Q33308569-C9F6B43E-7CD7-4AD9-9C7D-F8497EE263BFQ34631718-306DC63B-DB7F-4812-B855-9FDED6C3AC0DQ35688485-9992AA13-A903-45AC-B3BF-445FF537911DQ35776844-DE37C8AA-87ED-4F66-8583-7A4F59D6E9EFQ36959071-E3E7D27E-F4E8-4E00-ADDC-28016F6EE464Q37101834-C514FB96-6896-45F7-9D6C-2D079C4B141BQ37603769-1C9A0DF0-FB48-4305-8F0B-8194E8EF75A9Q42474921-73935E7C-0600-4943-891B-27103EBBBB7BQ42486235-ADC04D35-ABBF-4330-B819-E246FA2391E3Q47738098-C0BDFE2A-D8CC-4077-9CF3-5A85C6C72145Q48248520-5246747D-3932-46DA-A83F-06C3E094A8E0Q48473600-50ED8CBF-E8DD-44AD-A90D-D2267E86173DQ91655548-AE938BAC-DF9D-45CB-B9DA-89C653521CBAQ93153044-AC3FE0E2-65DB-48D4-AF9B-42F1EC4BF575
P50
description
pharmacologist
@en
wetenschapper
@nl
հետազոտող
@hy
name
Zixiu Xiang
@ast
Zixiu Xiang
@en
Zixiu Xiang
@es
Zixiu Xiang
@nl
Zixiu Xiang
@sl
type
label
Zixiu Xiang
@ast
Zixiu Xiang
@en
Zixiu Xiang
@es
Zixiu Xiang
@nl
Zixiu Xiang
@sl
prefLabel
Zixiu Xiang
@ast
Zixiu Xiang
@en
Zixiu Xiang
@es
Zixiu Xiang
@nl
Zixiu Xiang
@sl
P106
P1153
7102139058
P21
P31
P4012
P496
0000-0002-1678-209X