Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
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Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsSubtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disordersChemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAMAllostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesA selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learningDiscovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsAlzheimer's disease: Targeting the Cholinergic SystemMini Review: Anticholinergic Activity as a Behavioral Pathology of Lewy Body Disease and Proposal of the Concept of "Anticholinergic Spectrum Disorders"The antipsychotic potential of muscarinic allosteric modulationAllosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseAllosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in miceTargeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophreniaTargeting glutamate synapses in schizophreniaBeyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsA novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningSelective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic propertiesHippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesSynthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorAllosteric Modulation of Muscarinic Acetylcholine Receptors.Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation.Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling biasDeletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach.Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor
P2860
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P2860
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Novel selective allosteric act ...... ychotic-like activity in rats.
@en
type
label
Novel selective allosteric act ...... ychotic-like activity in rats.
@en
prefLabel
Novel selective allosteric act ...... ychotic-like activity in rats.
@en
P2093
P2860
P50
P1476
Novel selective allosteric act ...... sychotic-like activity in rats
@en
P2093
Albert A Davis
Alexander S Kane
Allan I Levey
Ariel Y Deutch
Ashley E Brady
Carrie K Jones
J Phillip Kennedy
James J Lah
M Sib Ansari
Mohammed Noor Tantawy
P2860
P304
10422-10433
P356
10.1523/JNEUROSCI.1850-08.2008
P407
P577
2008-10-01T00:00:00Z