UL5, a protein required for HSV DNA synthesis: genetic analysis, overexpression in Escherichia coli, and generation of polyclonal antibodies.
about
The DNA helicase-primase complex as a target for herpes viral infectionInhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complexThe herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartmentsHerpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products.Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteinsSimian varicella virus gene expression during acute and latent infection of rhesus macaques.The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent nucleoside triphosphatase.Use of transdominant mutants of the origin-binding protein (UL9) of herpes simplex virus type 1 to define functional domains.Characterization of ICP6::lacZ insertion mutants of the UL15 gene of herpes simplex virus type 1 reveals the translation of two proteins.Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer templateThe UL5 gene of herpes simplex virus type 1: isolation of a lacZ insertion mutant and association of the UL5 gene product with other members of the helicase-primase complex.The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype.The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture.The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for functionThe UL8 subunit of the herpes simplex virus helicase-primase complex is required for efficient primer utilization.Scanning concentration correlation spectroscopy using the confocal laser microscopeHerpes simplex virus type 1 DNA synthesis requires the product of the UL8 gene: isolation and characterization of an ICP6::lacZ insertion mutation.The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.The UL5 and UL52 subunits of the herpes simplex virus type 1 helicase-primase subcomplex exhibit a complex interdependence for DNA binding.Viral proteins containing the purine NTP-binding sequence pattern.A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome.Replacement of gly815 in helicase motif V alters the single-stranded DNA-dependent ATPase activity of the herpes simplex virus type 1 helicase-primase.Helicase-Primase Inhibitors: A New Approach to Combat Herpes Simplex Virus and Varicella Zoster Virus
P2860
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P2860
UL5, a protein required for HSV DNA synthesis: genetic analysis, overexpression in Escherichia coli, and generation of polyclonal antibodies.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@en
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@nl
type
label
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@en
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@nl
prefLabel
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@en
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@nl
P921
P1433
P1476
UL5, a protein required for HS ...... tion of polyclonal antibodies.
@en
P304
P356
10.1016/0042-6822(88)90507-7
P407
P577
1988-10-01T00:00:00Z