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Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndromeA lymphatic defect causes ocular hypertension and glaucoma in miceMutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.Complement and diseases: defective alternative pathway control results in kidney and eye diseases.Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome.Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells.Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation.Thrombotic microangiopathies: new insights and new challenges.Monitoring and modeling treatment of atypical hemolytic uremic syndrome.Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2: An Editorial Highlight for 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transductioC3 deposition glomerulopathy due to a functional factor H defectDifferent factor H-related protein patterns in siblings with typical hemolytic uremic syndromeFactor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formationFocused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
Stefan Heinen
@ast
Stefan Heinen
@en
Stefan Heinen
@es
Stefan Heinen
@nl
Stefan Heinen
@sl
type
label
Stefan Heinen
@ast
Stefan Heinen
@en
Stefan Heinen
@es
Stefan Heinen
@nl
Stefan Heinen
@sl
prefLabel
Stefan Heinen
@ast
Stefan Heinen
@en
Stefan Heinen
@es
Stefan Heinen
@nl
Stefan Heinen
@sl
P106
P21
P31
P496
0000-0001-5800-6593