F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.
about
Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Podophyllotoxin derivatives: a patent review (2012 - 2014).Synthesis and Biological Evaluation of Novel Aromatic Imide-Polyamine Conjugates.Discovery bioanalysis and in vivo pharmacology as an integrated process: a case study in oncology drug discovery.Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts.An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters.Polyamines and Cancer.Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ
P2860
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P2860
F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@en
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@nl
type
label
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@en
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@nl
prefLabel
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@en
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@nl
P2093
P2860
P356
P1433
P1476
F14512, a polyamine-vectorized ...... inical anti-leukemic activity.
@en
P2093
A Kruczynski
E Fournier
I Vandenberghe
J-P Annereau
L Créancier
P2860
P2888
P304
P356
10.1038/LEU.2013.108
P577
2013-04-09T00:00:00Z