MED12 mutations in leiomyosarcoma and extrauterine leiomyoma. - Wikidata - awgldk - TriplyDB

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

http://www.wikidata.org/entity/Q54280261

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Mediator kinase module and human tumorigenesis Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.Cytogenetically normal uterine leiomyomas without MED12-mutations - a source to identify unknown mechanisms of the development of uterine smooth muscle tumors.Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia Tissue-specific stem cells in the myometrium and tumor-initiating cells in leiomyoma.MED12 exon 2 mutations in phyllodes tumors of the breast Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.No REST for fibroids.Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases.Genetic heterogeneity in leiomyomas of deep soft tissue.Malignant mesenchymal tumors of the uterus - time to advocate a genetic classification.Molecular characteristics of uterine sarcomas.Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability.A rare coincidence of different types of driver mutations among uterine leiomyomas (UL).Role of Transforming Growth Factor β in Uterine Fibroid Biology.Uterine fibroids - what's new?Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma.Comprehensive screening for MED12 mutations in gynaecological mesenchymal tumours identified morphologically distinctive mixed epithelial and stromal tumours.Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors.Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients.MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours.MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.MED12 exon 2 mutation as a highly sensitive and specific marker in distinguishing phyllodes tumours from other spindle neoplasms of the breast.Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade.Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.Benign Smooth Muscle Tumors (Leiomyomas) of Deep Somatic Soft Tissue

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MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

http://www.wikidata.org/entity/Q54280261

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@en

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@nl

type

label

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@en

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@nl

prefLabel

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@en

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

@nl

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MODPATHOL.2012.203

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Modern Pathology

P1476

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma

@en

P2093

Adrian Mariño-Enriquez

http://www.w3.org/2001/XMLSchema#string

Chandrajit P Raut

http://www.w3.org/2001/XMLSchema#string

Grant Eilers

http://www.w3.org/2001/XMLSchema#string

Jaime Slater

http://www.w3.org/2001/XMLSchema#string

Jonathan A Fletcher

http://www.w3.org/2001/XMLSchema#string

Marisa R Nucci

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Meijun Zhu

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Suzanne George

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Yuexiang Wang

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P2860

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II

A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome).

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

MED12 alterations in both human benign and malignant uterine soft tissue tumors.

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome.

Genetic heterogeneity among uterine leiomyomata: insights into malignant progression.

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.

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modpathol.2012.203

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10.1038/MODPATHOL.2012.203

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5

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26

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Sabrina Angelini

Gloria Ravegnini

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2012-12-07T00:00:00Z

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233880497

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