Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

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http://www.wikidata.org/entity/Q54452193
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5Engineered sarafotoxins as tissue inhibitor of metalloproteinases-like matrix metalloproteinase inhibitors.Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.FRET-based and other fluorescent proteinase probes.Using fluorogenic peptide substrates to assay matrix metalloproteinases.Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.Human copper transporter 1 lacking O-linked glycosylation is proteolytically cleaved in a Rab9-positive endosomal compartment.Synthesis and biological applications of collagen-model triple-helical peptides.Accelerating trypsin digestion: the immobilized enzyme reactor.Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates.Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β.MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity.The beta amyloid peptide can act as a modular aggregation domain.The role of Tyr71 in Streptomyces trypsin on the recognition mechanism of structural protein substrates.
P2860

Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

Item
http://www.wikidata.org/entity/Q54452193
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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name
Substrate conformation modulat ...... unctionally diverse proteases.
@en
Substrate conformation modulates aggrecanase
@nl
type
label
Substrate conformation modulat ...... unctionally diverse proteases.
@en
Substrate conformation modulates aggrecanase
@nl
prefLabel
Substrate conformation modulat ...... unctionally diverse proteases.
@en
Substrate conformation modulates aggrecanase
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Substrate conformation modulat ...... unctionally diverse proteases.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698