Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.
about
A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their FunctionsEffects of Glycosylation on the Enzymatic Activity and Mechanisms of ProteasesProteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-GlycosylationIdentification of Protein Palmitoylation Inhibitors from a Scaffold Ranking LibrarySAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrateComparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-α Release from Activated Microglia and TNF-α Converting Enzyme ActivityThe mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptorsGlycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathwaysActivity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosisMechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation.Clinical implications of compounds designed to inhibit ECM-modifying metalloproteinases.Non-small-cell lung carcinoma: role of the Notch signaling pathway.Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation.Measurement of Protease Activities Using Fluorogenic Substrates.Considerations on inhibition approaches for proinflammatory functions of ADAM proteases.TAILS N-Terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.
P2860
Q26749364-7141A963-FBAE-455B-8D1A-DFAEFF3EB0ADQ28069869-8E317D75-8DE5-4932-B4B0-4C3B02D1FC03Q28468416-5B8BD99F-DEC5-4A72-91A5-AADAEC4AC2E3Q28821795-45439EF2-1F0A-41EF-B886-CFC04E4E33D0Q33645235-900E8869-5CE1-48A5-ABBF-689DA948FA8EQ33685019-84D0A2DD-8147-4A9B-BCC9-DDF1E76A290AQ34360507-C86301D2-FFAB-4CF6-BFBD-5F2994CB9623Q34748690-93014DAF-6D6F-4AD3-9790-72AC43DD0BD7Q35101344-DD736F9E-0040-43F1-B158-87671BE018E8Q36332111-6E5C31A4-B842-4D2C-921C-FE7472476A0BQ36932188-77429AE4-A26B-44EC-B32B-3E4C26389BC2Q37312014-1C4E030E-850A-4465-87E7-25D8908FBC0EQ37697460-02F7C310-B096-4BFF-9FF3-9B964F462802Q37743354-7B556384-22D6-4A22-8759-5452BE446B2BQ38430546-41865AA6-8847-46F2-AAE2-419CE39D5059Q39139927-B17EEA32-B627-4922-8EE4-784CEE2AA5C6Q39308095-F6753F5D-2095-4D50-8402-826D90BA24C9Q46450905-A7A04446-D3E1-4992-B2A3-F47635EF3FE3Q50109709-1AA96151-9821-44DF-B5E9-9E235DDF6614Q50495797-D55932EC-F31F-4BA1-B855-48F68EEB640EQ52338988-C3352C48-F257-4DBA-9C00-308D350A54AE
P2860
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@ast
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@en
Discovery of novel inhibitors of a disintegrin and metalloprotease 17
@nl
type
label
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@ast
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@en
Discovery of novel inhibitors of a disintegrin and metalloprotease 17
@nl
prefLabel
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@ast
Discovery of novel inhibitors ...... d non-glycosylated substrates.
@en
Discovery of novel inhibitors of a disintegrin and metalloprotease 17
@nl
P2093
P2860
P356
P1476
Discovery of novel inhibitors ...... nd non-glycosylated substrates
@en
P2093
Gregg B Fields
Laura Maida
Marc Giulianotti
Mare Cudic
Nina Bionda
Richard A Houghten
P2860
P304
36473-36487
P356
10.1074/JBC.M112.389114
P407
P577
2012-08-27T00:00:00Z