about
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2BIdentification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formationCoping with stress: eIF2 kinases and translational controlMechanisms of protein balance in skeletal muscle.EXtENDINg beta cell survival by UPRegulating ATF4 translation.Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα.Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.The role of leucine and its metabolites in protein and energy metabolism.GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation.Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction.Remodeling of lipid metabolism by dietary restriction of essential amino acidsGeneral control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in miceThe eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.Defining meal requirements for protein to optimize metabolic roles of amino acids.Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.Post-meal responses of elongation factor 2 (eEF2) and adenosine monophosphate-activated protein kinase (AMPK) to leucine and carbohydrate supplements for regulating protein synthesis duration and energy homeostasis in rat skeletal muscle.Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle.Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing.Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice.The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats.Fragmented population structure of plasmodium falciparum in a region of declining endemicity.Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise.Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats.Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.Homeostatic responses to amino acid insufficiency.Feeding meals containing soy or whey protein after exercise stimulates protein synthesis and translation initiation in the skeletal muscle of male ratsTXNIP switches tracks toward a terminal UPRAscorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise programAge modulates liver responses to asparaginase-induced amino acid stress in miceDietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Tracy G Anthony
@nl
Tracy G Anthony
@sl
Tracy G. Anthony
@en
Tracy G. Anthony
@es
type
label
Tracy G Anthony
@nl
Tracy G Anthony
@sl
Tracy G. Anthony
@en
Tracy G. Anthony
@es
prefLabel
Tracy G Anthony
@nl
Tracy G Anthony
@sl
Tracy G. Anthony
@en
Tracy G. Anthony
@es
P106
P1153
7102538640
P31
P496
0000-0002-8586-5884