Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
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Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pCrystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase IMetabolic reprogramming and metabolic dependency in T cellsEngineering of Helicobacter pylori L-asparaginase: characterization of two functionally distinct groups of mutantsThe eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginaseRole of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumorsThe glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.From Krebs to clinic: glutamine metabolism to cancer therapy.Asparagine synthetase: a new potential biomarker in ovarian cancer.Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia.GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.Structural Insight into Substrate Selectivity of Erwinia chrysanthemi L-asparaginaseEukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine.General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in miceThe eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.Asparaginase in the treatment of non-ALL hematologic malignancies.Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase ActivityA clinically attainable dose of L-asparaginase targets glutamine addiction in lymphoid cell lines.Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.Creation of a producent, optimization of expression, and purification of recombinant Yersinia pseudotuberculosis L-asparaginase.Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism.A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran.Microchip CE-LIF method for the hydrolysis of L-glutamine by using L-asparaginase enzyme reactor based on gold nanoparticle.Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study.Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T and B cell acute lymphoblastic leukemias in vivo.High yield expression of novel glutaminase free L-asparaginase II of Pectobacterium carotovorum MTCC 1428 in Bacillus subtilis WB800N.Molecular dynamic simulations of Escherichia coli L-asparaginase to illuminate its role in deamination of asparagine and glutamine residues.The Modified Heparin-Binding L-Asparaginase of Wolinella succinogenes.Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathways.Homeostatic responses to amino acid insufficiency.Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine.
P2860
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P2860
Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Role of glutamine depletion in ...... s responses to L-asparaginase.
@en
Role of glutamine depletion in ...... s responses to L-asparaginase.
@nl
type
label
Role of glutamine depletion in ...... s responses to L-asparaginase.
@en
Role of glutamine depletion in ...... s responses to L-asparaginase.
@nl
prefLabel
Role of glutamine depletion in ...... s responses to L-asparaginase.
@en
Role of glutamine depletion in ...... s responses to L-asparaginase.
@nl
P2093
P2860
P356
P1476
Role of glutamine depletion in ...... ss responses to L-asparaginase
@en
P2093
Carla J Aldrich
Donald L Durden
Izolda Mileva
L Morgan Oberle
Leslie O Goodwin
Margaret A McNurlan
Piyawan Bunpo
Ronald C Wek
Sheree A Wek
Xue Ping Wang
P2860
P304
31222-31233
P356
10.1074/JBC.M604511200
P407
P577
2006-08-24T00:00:00Z