Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.
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Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasisHFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expressionCD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expressionA time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosisThe liver-specific microRNA miR-122 controls systemic iron homeostasis in miceHepcidin: A Promising Therapeutic Target for Iron Disorders: A Systematic ReviewHepcidin: regulation of the master iron regulatorRegulation of Iron Metabolism by Hepcidin under Conditions of InflammationMurine mutants in the study of systemic iron metabolism and its disorders: an update on recent advancesMechanisms of mammalian iron homeostasisMolecular basis of HFE-hemochromatosis.Hepcidin and iron regulation, 10 years later.Iron regulation by hepcidinDifferential HFE gene expression is regulated by alternative splicing in human tissuesAge-dependent retinal iron accumulation and degeneration in hepcidin knockout miceA computational model of liver iron metabolismEnhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasisHepcidin and sports anemiaTargeting iron metabolism in drug discovery and deliveryMass spectrometry analysis of hepcidin peptides in experimental mouse models.Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosisHepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in miceGastrins, iron homeostasis and colorectal cancerIn situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.HJV and HFE Play Distinct Roles in Regulating Hepcidin.Hereditary hemochromatosis and transferrin receptor 2A systems biology approach to iron metabolism.Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice.Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or HfeUnraveling mechanisms regulating systemic iron homeostasis.Expression and function of iron-regulatory proteins in retina.The liver: conductor of systemic iron balance.Bmp6 expression can be regulated independently of liver iron in mice.The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease.
P2860
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P2860
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@en
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@nl
type
label
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@en
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@nl
prefLabel
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@en
Combined deletion of Hfe and t ...... of hepcidin and iron overload.
@nl
P50
P356
P1433
P1476
Combined deletion of Hfe and t ...... of hepcidin and iron overload
@en
P2093
Emily M Crampton
Lesa Summerville
P304
P356
10.1002/HEP.23198
P407
P577
2009-12-01T00:00:00Z