Three-dimensional structure, specificity and catalytic mechanism of renin.
about
Profile analysis: detection of distantly related proteinsHuman renin gene: structure and sequence analysisKnowledge-based model building of proteins: concepts and examplesA brief history of macromolecular crystallography, illustrated by a family tree and its Nobel fruitsSolution structure of a D,L-alternating oligonorleucine as a model of double-stranded antiparallel beta-helixHigh-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzymeX-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitorKnowledge-Based Protein ModelingOptimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designingMolecular cloning of rat renin cDNA and its gene.Comparative Modeling of Protein Structure-Progress and ProspectsGenome structure and expression of the ev/J family of avian endogenous viruses.Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 ratFolding kinetics of designer proteins. Application of the diffusion-collision model to a de novo designed four-helix bundleResponse of plasma prorenin and active renin to chronic and acute alterations of renin secretion in normal humans. Studies using a direct immunoradiometric assay.New monoclonal antibodies directed against human renin. Powerful tools for the investigation of the renin systemStructural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolases.Structure of the human renin geneEvolution of aspartyl proteases by gene duplication: the mouse renin gene is organized in two homologous clusters of four exonsStructure of human renin and expression of the renin gene.Molecular drug targets and structure based drug design: A holistic approach.Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression.Comparative modeling of proteins in the design of novel renin inhibitors.Protein model structure evaluation using the solvation free energy of folding.Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance.QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα.Molecular dynamics studies on both bound and unbound renin protease.Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry.A comparison of several similarity indices used in the classification of protein sequences: a multivariate analysisMolecular studies of human renin structure and synthesis using monoclonal antibodies.Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.CREDO: a structural interactomics database for drug discovery.Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat.Computer-aided design in protein engineering.Discovery of new sites for drug binding to the hypertension-related renin-angiotensinogen complex.The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion.Celebrating structural biologyThe development of the direct renin inhibitor aliskiren: treating hypertension and beyondThe catalytic mechanism of mouse renin studied with QM/MM calculations
P2860
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P2860
Three-dimensional structure, specificity and catalytic mechanism of renin.
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年学术文章
@wuu
1983年学术文章
@zh-cn
1983年学术文章
@zh-hans
1983年学术文章
@zh-my
1983年学术文章
@zh-sg
1983年學術文章
@yue
1983年學術文章
@zh
1983年學術文章
@zh-hant
name
Three-dimensional structure, specificity and catalytic mechanism of renin.
@en
Three-dimensional structure, specificity and catalytic mechanism of renin.
@nl
type
label
Three-dimensional structure, specificity and catalytic mechanism of renin.
@en
Three-dimensional structure, specificity and catalytic mechanism of renin.
@nl
prefLabel
Three-dimensional structure, specificity and catalytic mechanism of renin.
@en
Three-dimensional structure, specificity and catalytic mechanism of renin.
@nl
P356
P1433
P1476
Three-dimensional structure, specificity and catalytic mechanism of renin.
@en
P2093
P2860
P2888
P304
P356
10.1038/304273A0
P407
P50
P577
1983-07-01T00:00:00Z
P6179
1038177308