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The role of the central flexible region on the aggregation and conformational properties of human ataxin-3A single-point mutation in the extreme heat- and pressure-resistant sso7d protein from sulfolobus solfataricus leads to a major rearrangement of the hydrophobic coreSingle-domain protein A-engineered magnetic nanoparticles: toward a universal strategy to site-specific labeling of antibodies for targeted detection of tumor cells.Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules.The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic Josephin domain in monomeric form, while leaving the oligomers unaffectedHsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.Immobilization of carboxypeptidase from Sulfolobus solfataricus on magnetic nanoparticles improves enzyme stability and functionality in organic media.Peptide-nanoparticle ligation mediated by cutinase fusion for the development of cancer cell-targeted nanoconjugates.The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular ModelNegatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations.Biotechnological approaches toward nanoparticle biofunctionalization.Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in Cancer Cells.Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition.Highly efficient production of anti-HER2 scFv antibody variant for targeting breast cancer cells.Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling.Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles.A mutation in polynucleotide phosphorylase from Escherichia coli impairing RNA binding and degradosome stability.Dependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf.Structural features responsible for kinetic thermal stability of a carboxypeptidase from the archaebacterium Sulfolobus solfataricus.The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.Ribonucleases from the extreme thermophilic archaebacterium S. solfataricus.The role of phenylalanine 31 in maintaining the conformational stability of ribonuclease P2 from Sulfolobus solfataricus under extreme conditions of temperature and pressure.Structure prediction and functional analysis of KdsD, an enzyme involved in lipopolysaccharide biosynthesis.A conserved loop in polynucleotide phosphorylase (PNPase) essential for both RNA and ADP/phosphate binding.Thermal stability and DNA binding activity of a variant form of the Sso7d protein from the archeon Sulfolobus solfataricus truncated at leucine 54.Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).Polynucleotide phosphorylase-based photometric assay for inorganic phosphate.Guanidine-induced unfolding of the Sso7d protein from the hyperthermophilic archaeon Sulfolobus solfataricus.Interaction of selected divalent metal ions with human ataxin-3 Q36.Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.Regulation of Escherichia coli polynucleotide phosphorylase by ATP.A High Sensitivity Biosensor to detect the presence of perfluorinated compounds in environment.Differential scanning calorimetry study of the thermodynamic stability of some mutants of Sso7d from Sulfolobus solfataricus.The conformational ensemble of the disordered and aggregation-protective 182-291 region of ataxin-3.Molecular cloning, nucleotide sequence and expression of a Sulfolobus solfataricus gene encoding a class II fumarase.Different ataxin-3 amyloid aggregates induce intracellular Ca(2+) deregulation by different mechanisms in cerebellar granule cells.Glucose-6-phosphate dehydrogenase deficiency in Italian blood donors: prevalence and molecular defect characterization.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Paolo Tortora
@ast
Paolo Tortora
@en
Paolo Tortora
@es
Paolo Tortora
@nl
Paolo Tortora
@sl
type
label
Paolo Tortora
@ast
Paolo Tortora
@en
Paolo Tortora
@es
Paolo Tortora
@nl
Paolo Tortora
@sl
prefLabel
Paolo Tortora
@ast
Paolo Tortora
@en
Paolo Tortora
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Paolo Tortora
@nl
Paolo Tortora
@sl
P106
P31
P496
0000-0001-5234-601X