PI3Kβ plays a critical role in neutrophil activation by immune complexes.
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Signaling by the phosphoinositide 3-kinase family in immune cellsNovel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli CellsPrevalence of pemphigus and pemphigoid autoantibodies in the general populationNeutrophil cell surface receptors and their intracellular signal transduction pathways.Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.Mechanisms of Autoantibody-Induced Pathology.Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survivalThe phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.Two birds with one stone: dual p110δ and p110γ inhibitionAntitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinomaThe Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesSiglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisitaSignaling via class IA Phosphoinositide 3-kinases (PI3K) in human, breast-derived cell linesPI3Kδ and primary immunodeficiencies.Streptococcal co-infection augments Candida pathogenicity by amplifying the mucosal inflammatory response.G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.Model systems duplicating epidermolysis bullosa acquisita: a methodological review.Selective PI3Kδ inhibitors, a review of the patent literature.Crossroads of PI3K and Rac pathways.Intracellular signalling during neutrophil recruitment.PI3K inhibitors in inflammation, autoimmunity and cancer.Immune mechanism-targeted treatment of experimental epidermolysis bullosa acquisita.Molecules in medicine mini-review: isoforms of PI3K in biology and disease.Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options.Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita.Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita.Cross-talk between Rho GTPases and PI3K in the neutrophil.Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice.Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies.Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils.The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita.Evaluation of Anti-Inflammatory Activity of Citrus latifolia Tanaka Essential Oil and Limonene in Experimental Mouse Models.Granulocyte-dependent autoantibody-induced skin blistering.The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa AcquisitaCoincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.
P2860
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P2860
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@en
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@nl
type
label
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@en
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@nl
prefLabel
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@en
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@nl
P2093
P50
P1433
P1476
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
@en
P2093
Anja Fritsch
Anne Segonds-Pichon
Bart Vanhaesebroeck
David Oxley
George Damoulakis
Jatinder Juss
Karen E Anderson
Keith Davidson
Misa Hirose
Suhasini Kulkarni
P356
10.1126/SCISIGNAL.2001617
P50
P577
2011-04-12T00:00:00Z