RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
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G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT SignalingSingle cell pattern formation and transient cytoskeletal arraysRho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular traffickingSubcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disordersThe therapeutic potential of targeting the PI3K pathway in pediatric brain tumorsRegulation and function of P-Rex family Rac-GEFsRegulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasisThe novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cellsAssembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer.PI3K and cancer: lessons, challenges and opportunitiesRapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans.PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.Essential role of Elmo1 in Dock2-dependent lymphocyte migrationRab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans.Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110αKras as a key oncogene and therapeutic target in pancreatic cancerPI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma.Drugging the undruggable RAS: Mission possible?ClipR-59 interacts with Elmo2 and modulates myoblast fusion.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers.A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanomaControl of the innate immune response by the mevalonate pathway.Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN lossPhosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization.Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.Classes of phosphoinositide 3-kinases at a glance.PI3Kδ and primary immunodeficiencies.Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells.Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.
P2860
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P2860
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@ast
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@en
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@nl
type
label
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@ast
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@en
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@nl
prefLabel
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@ast
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@en
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@nl
P2093
P2860
P1433
P1476
RAS and RHO families of GTPase ...... hoinositide 3-kinase isoforms.
@en
P2093
Beth Reason
Gordon Stamp
Inge de Krijger
Kornelia Fritsch
Madhu S Kumar
Markus Diefenbacher
Ralph Fritsch
Roger George
P2860
P304
P356
10.1016/J.CELL.2013.04.031
P407
P577
2013-05-01T00:00:00Z