about
Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its InhibitionNew nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the targetSalmonella enterica serovar Typhimurium growth is inhibited by the concomitant binding of Zn(II) and a pyrrolyl-hydroxamate to ZnuA, the soluble component of the ZnuABC transporterDiaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4Antimycobacterial pyrroles: synthesis, anti-Mycobacterium tuberculosis activity and QSAR studies.Competing sigmatropic shift rearrangements in excited allyl radicals.Natural products as antifungal agents against clinically relevant pathogens.Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compoundsDiscovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.Discovery of in vitro antitubercular agents through in silico ligand-based approaches.Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.Human terminal deoxynucleotidyl transferases as novel targets for anticancer chemotherapy.Human immunodeficiency virus type 1 (HIV-1) integration: a potential target for microbicides to prevent cell-free or cell-associated HIV-1 infection.Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of actionNovel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activitiesPhenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives.Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors.New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruziActivity of caffeic acid derivatives against Candida albicans biofilm.6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action.Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.Inhibiting the HIV integration process: past, present, and the future.New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H.Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives.Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity.HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein.Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 2).Arylthiopyrrole (AThP) derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis, structure-activity relationships, and docking studies (part 1).Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase.2H-Pyrrolo[3,4-b] [1,5]benzothiazepine derivatives as potential inhibitors of HIV-1 reverse transcriptase.Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.Exploring the anti-biofilm activity of cinnamic acid derivatives in Candida albicans.2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays.N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.
P50
Q27684715-790BEFE3-9508-41BA-B00E-CEE9A7BE11ABQ27685405-4864EFA2-E379-44B5-A618-EA258F1F8132Q27703219-F8618466-C820-4352-9D8B-7FA68E6A6428Q28550770-44A380AC-6B9D-4DAE-B686-6943647240E0Q31407411-DD135EE9-C038-4706-B5CF-44AB9DEAE199Q33330424-EBA0A68F-2BD0-4809-894C-7EF7B004CBA1Q33582329-04F661AF-217F-41A3-B5BE-73D770FA8752Q34372481-6E4B0645-606A-4154-B4B8-5B1B5266CCD9Q35091567-4836F10D-95C4-44C0-A636-544869387B32Q35684884-CC91EBB2-0BA8-4A82-8BA5-19CAEE6E8929Q35938327-6DEA4B15-0DB9-4B12-8890-40D1B9B56324Q36033940-245F25F9-A95E-4775-A3A8-09E58261605CQ36252376-8E9FA909-E597-4D28-B3AE-CE1B12E1AADEQ36570030-09992AA9-ED34-4CC0-9892-8E0F116B3116Q36744775-709382A8-75A9-47DA-9B12-D19EBE8973B9Q37014638-79688AD4-631E-40FF-B0CF-97C458B32D8DQ37107512-21671660-60A1-4D8D-A525-773CBE03C458Q37695391-850EDABA-10A7-45D2-B9B5-1B867E0EDFFAQ38968700-E7CBAA29-7A75-4C35-9AD0-F0A4FA3D6580Q38976663-4CDC1BF9-3AC9-4EE8-AB4A-4DC270095E0DQ39012627-A042FDC5-264B-4C34-A1FB-00C935E91C55Q39019743-B29BE444-6366-4809-A271-140F1E191B7FQ39078832-047825F6-1B3F-48D6-8D06-E01E00A8BECBQ39142877-940760F7-5551-4A09-80BF-6AC3811151B3Q39323458-8C3B5BF1-D0B6-4B17-954E-78932F92E80FQ39329294-0A918E26-A68A-4372-97E3-7100DEA71952Q39352071-81502ECB-E68D-4DE3-A9D2-C544AE4D2B25Q39360609-6D0A7394-0B54-4538-9F09-0BEB255C6CF8Q39398890-E2861946-6C51-43C4-95BC-04FEBE1E5F14Q39536678-90F1720C-69EB-4367-87C4-58FC1FEFF5B5Q40162203-2BC84D77-8FD4-406A-86CB-0B84120E46AAQ40211081-35995982-7510-4981-934E-EA6A224137A2Q40211088-E6154038-5D25-4630-B881-111A5DA07B84Q40246588-29097F76-E08D-4D29-A4AE-1CCDBFBA9495Q40271872-56DD0E21-A5C6-4C88-A6C9-781B6C100298Q40418592-A4A4A20B-A0D1-43CC-935D-B17091B89583Q40420712-FDC2F235-43E0-4C9A-8E3D-E8DF95EB7E0BQ40454576-D76FE9C2-816E-4027-88A8-8D0A5B762ADFQ40603490-19947F5B-1DAC-4439-8179-E369553A9947Q41242092-F646D7A6-CA8C-4923-A6F8-BF1E839E31FB
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Roberto Di Santo
@ast
Roberto Di Santo
@en
Roberto Di Santo
@es
Roberto Di Santo
@nl
Roberto Di Santo
@sl
type
label
Roberto Di Santo
@ast
Roberto Di Santo
@en
Roberto Di Santo
@es
Roberto Di Santo
@nl
Roberto Di Santo
@sl
prefLabel
Roberto Di Santo
@ast
Roberto Di Santo
@en
Roberto Di Santo
@es
Roberto Di Santo
@nl
Roberto Di Santo
@sl
P106
P1153
7004256372
P21
P31
P496
0000-0002-4279-7666