Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.
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Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseBiophysical Aspects of T Lymphocyte Activation at the Immune SynapseStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC DiscriminationMicro- and nanoscale engineering of cell signalingRegulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasmαβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapyLinking form to function: Biophysical aspects of artificial antigen presenting cell designSignaling at neuro/immune synapsesMechanical regulation of T-cell functionsForce generation upon T cell receptor engagementMyosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formationTwo-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discriminationT cell activation requires force generationF-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activationT Lymphocyte Myosin IIA is Required for Maturation of the Immunological SynapsePhotocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.CD28 and CD3 have complementary roles in T-cell traction forces.Cytoskeletal forces during signaling activation in Jurkat T-cells.F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse.DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.Actin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityConstitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments.Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells.Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clustersTCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length.The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif.T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobilityUse of TIRF to Monitor T-Lymphocyte Membrane Dynamics with Submicrometer and Subsecond Resolution.Mechanosensing in T lymphocyte activationMembrane dynamics shape TCR-generated signaling.A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Substrate rigidity regulates human T cell activation and proliferationMicropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.Actin engine in immunological synapseInsights from in situ analysis of TCR-pMHC recognition: response of an interaction network.Tapping out a mechanical code for T cell triggeringStructural and biophysical insights into the role of CD4 and CD8 in T cell activation.Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation
P2860
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P2860
Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
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name
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@en
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@nl
type
label
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@en
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@nl
prefLabel
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@en
Cutting Edge: mechanical force ...... lex can trigger TCR signaling.
@nl
P2093
P356
P1476
Cutting Edge: mechanical force ...... plex can trigger TCR signaling
@en
P2093
Andre Lieber
Bing-Mae Chen
Lung-Sen Kao
Mi-Hua Tao
Pei-Chun Wu
Steve R Roffler
Ya-Chen Li
P304
P356
10.4049/JIMMUNOL.0900775
P407
P577
2010-04-30T00:00:00Z