Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. - Wikidata - awgldk - TriplyDB

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

http://www.wikidata.org/entity/Q55044269

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Shared molecular and functional frameworks among five complex human disorders: a comparative study on interactomes linked to susceptibility genes Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 The expanding genetic overlap between multiple sclerosis and type I diabetes A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3 Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.Inducing and Administering Tregs to Treat Human Disease Insights into type 1 diabetes from the autoimmune polyendocrine syndromes Daclizumab therapy for multiple sclerosis Recent advances in the genetics of autoimmune disease Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease Methodological challenges of genome-wide association analysis in Africa A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.Rare variants create synthetic genome-wide associations Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes.Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.Haplotypic analysis of Wellcome Trust Case Control Consortium data.IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis A probabilistic approach for SNP discovery in high-throughput human resequencing data.Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.Accounting for chance in the calculus of autoimmune disease Transcriptional rewiring of the sex determining dmrt1 gene duplicate by transposable elements Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells Fluorescence intensity normalisation: correcting for time effects in large-scale flow cytometric analysis.A powerful association test of multiple genetic variants using a random-effects model.Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention The type I diabetes association of the IL2RA locus.Daclizumab high-yield process in the treatment of relapsing-remitting multiple sclerosis

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

http://www.wikidata.org/entity/Q55044269

description

2007 nî lūn-bûn

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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type

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Nature Genetics

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Large-scale genetic fine mappi ...... 2RA region in type 1 diabetes.

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Christopher E Lowe

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David G Clayton

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Jason D Cooper

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Kirsi Bourget

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Linda S Wicker

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Mark Atkinson

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Rebecca Bailey

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Sarah Field

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Todd Brusko

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P2860

A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

A haplotype map of the human genome

The International HapMap Project

Haploview: analysis and visualization of LD and haplotype maps

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Multiplexed genotyping with sequence-tagged molecular inversion probes

HTRA1 promoter polymorphism in wet age-related macular degeneration

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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1074-1082

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10.1038/NG2102

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9

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39

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Vincent Plagnol

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2007-08-05T00:00:00Z

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6163446

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1017373644

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17676041

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type-1 diabetes