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Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteinsPar1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytesLGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA PathwaysPhosphorylation-dependent interaction between tumor suppressors Dlg and LglA mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organizationLGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complexPar3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical PinsLGN regulates mitotic spindle orientation during epithelial morphogenesis.A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamicsRegulation of myosin activation during cell-cell contact formation by Par3-Lgl antagonism: entosis without matrix detachmentDifferential regulation of myosin X movements by its cargos, DCC and neogenin.Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cellsReduced expression of the immediate-early protein IE0 enables efficient replication of Autographa californica multiple nucleopolyhedrovirus in poorly permissive Spodoptera littoralis cellsDrp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis.The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division.Galpha/LGN-mediated asymmetric spindle positioning does not lead to unequal cleavage of the mother cell in 3-D cultured MDCK cells.miR-141 is a key regulator of renal cell carcinoma proliferation and metastasis by controlling EphA2 expression.Inhibition of PP2A activity confers a TRAIL-sensitive phenotype during malignant transformation.Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.Multiple mechanisms regulate NuMA dynamics at spindle poles.Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2.mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Quansheng Du
@ast
Quansheng Du
@en
Quansheng Du
@es
Quansheng Du
@nl
Quansheng Du
@sl
type
label
Quansheng Du
@ast
Quansheng Du
@en
Quansheng Du
@es
Quansheng Du
@nl
Quansheng Du
@sl
prefLabel
Quansheng Du
@ast
Quansheng Du
@en
Quansheng Du
@es
Quansheng Du
@nl
Quansheng Du
@sl
P108
P106
P1153
7202060122
P31
P496
0000-0003-4079-8662