about
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cellsClarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeletonAlternative splice variants of the USH3A gene Clarin 1 (CLRN1)CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell developmentOptogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularizationUsher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activationMassively parallel cis-regulatory analysis in the mammalian central nervous systemSevere retinal degeneration caused by a novel rhodopsin mutation.Imaging light responses of foveal ganglion cells in the living macaque eye.Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina.Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve.Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cellsTransport of truncated rhodopsin and its effects on rod function and degeneration.In vivo imaging of microscopic structures in the rat retinaMolecular evolution of adeno-associated virus for enhanced glial gene delivery.Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.Evaluation of patient-centered rehabilitation model targeting older persons with a hip fracture, including those with cognitive impairment.USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses.Visual stimulation switches the polarity of excitatory input to starburst amacrine cells.Remote control of neuronal activity with a light-gated glutamate receptor.Intravitreal injection of AAV2 transduces macaque inner retinaAAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retinaCRALBP supports the mammalian retinal visual cycle and cone vision.LiGluR restores visual responses in rodent models of inherited blindness.Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degenerationRibozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by ageAdaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retinaRole for a novel Usher protein complex in hair cell synaptic maturation.Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors.Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animalsNeuron-glia signaling in developing retina mediated by neurotransmitter spillover.Short hairpin RNA-mediated knockdown of VEGFA in Müller cells reduces intravitreal neovascularization in a rat model of retinopathy of prematurity.Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.Quantitative analyses of retinal vascular area and density after different methods to reduce VEGF in a rat model of retinopathy of prematurity.Targeting Müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity.Advances in AAV vector development for gene therapy in the retina.AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa.Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates
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description
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wetenschapper
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հետազոտող
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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John G. Flannery
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P106
P1153
7006021321
P21
P31
P496
0000-0002-0720-8897