about
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelNeighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocyclesApplication of ring-closing metathesis to Grb2 SH3 domain-binding peptides.Mitsunobu mischief: neighbor-directed histidine N(τ)-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles.Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues.Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.Construction of multiring frameworks by metal-free cascade reactions of stable isochromenylium tetrafluoroborate.Design and Synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the Preparation of Peptide Prodrugs Containing Phosphothreonine in Fully Protected FormTransformation of Reactive Isochromenylium Intermediates to Stable Salts and Their Cascade Reactions with OlefinsTotal Synthesis, Assignment of Absolute Stereochemistry, and Structural Revision of Chlorofusin
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Wenjian Qian
@ast
Wenjian Qian
@en
Wenjian Qian
@es
Wenjian Qian
@nl
Wenjian Qian
@sl
type
label
Wenjian Qian
@ast
Wenjian Qian
@en
Wenjian Qian
@es
Wenjian Qian
@nl
Wenjian Qian
@sl
prefLabel
Wenjian Qian
@ast
Wenjian Qian
@en
Wenjian Qian
@es
Wenjian Qian
@nl
Wenjian Qian
@sl
P108
P106
P1153
53983044200
P31
P496
0000-0002-0063-8405