about
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9aSpecific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatasePhosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinaseREDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligaseMammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesisThe role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.Control of mTORC1 signaling by the Opitz syndrome protein MID1.Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathwaysComparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.Targeting the mTOR signaling network in cancer.SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathwayGenotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Gary G. Chiang
@ast
Gary G. Chiang
@en
Gary G. Chiang
@es
Gary G. Chiang
@nl
Gary G. Chiang
@sl
type
label
Gary G. Chiang
@ast
Gary G. Chiang
@en
Gary G. Chiang
@es
Gary G. Chiang
@nl
Gary G. Chiang
@sl
prefLabel
Gary G. Chiang
@ast
Gary G. Chiang
@en
Gary G. Chiang
@es
Gary G. Chiang
@nl
Gary G. Chiang
@sl
P106
P1153
7005661566
P21
P31
P496
0000-0003-3004-7400