about
The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activitiesInterferon- Is Functionally an Interferon but Structurally Related to the Interleukin-10 FamilySelection of a Novel and Highly Specific Tumor Necrosis Factor (TNF ) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNF COMPLEXHuman interferon-lambda3 is a potent member of the type III interferon family.Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signalingFunctional IRF3 deficiency in a patient with herpes simplex encephalitis.The structure of human interferon lambda and what it has taught us.The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.Lambda Interferons: New Cytokines with Old Functions.Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.Rapid Uptake and Inhibition of Viral Propagation by Extracellular OAS1.A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.Defective RNA sensing by RIG-I in severe influenza virus infection.The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein.IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission.Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λType I and Type III Interferons Differ in Their Adjuvant Activities for Influenza VaccinesLength dependent activation of OAS proteins by dsRNAThe IFNL4 Gene Is a Noncanonical Interferon Gene with a Unique but Evolutionarily Conserved RegulationThe Influence of the rs30461 Single Nucleotide Polymorphism on IFN-λ1 Activity and SecretionInterferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietinDefective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenzaIdentification of an IRF3 variant and defective antiviral interferon responses in a patient with severe influenzaType I and III interferons disrupt lung epithelial repair during recovery from viral infection
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description
researcher
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wetenschapper
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հետազոտող
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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Hans Henrik Gad
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P106
P1153
25630217300
P21
P31
P496
0000-0001-8449-1115