Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年学术文章

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2018年學術文章

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Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

@en

Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

@en

Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury.

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P1476

Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury

@en

P2093

Caixia Wang

http://www.w3.org/2001/XMLSchema#string

Huaiqian Dai

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Jing Nie

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Mangmang Li

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Xiaochun Bai

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Zhi Xiong

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Zhipeng Zou

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P2860

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

mTOR signaling in growth control and disease

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR

Loss of hepatic DEPTOR alters the metabolic transition to fasting

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.

DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Cisplatin-associated nephrotoxicity and pathological events.

Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury

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441

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scholarly article

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10.1038/S41419-018-0483-3

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P433

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P478

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Zhenguo Chen

Q Song

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2018-05-01T00:00:00Z

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29670094

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5906659

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