about
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5Synthesis and antiangiogenic activity of N-alkylated levamisole derivativesTriangular prism-shaped β-peptoid helices as unique biomimetic scaffoldsSelectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranesProbing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTRβ-Peptoid Foldamers at Last.Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADHDesign, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.Peptoid-Peptide hybrid backbone architectures.Beta-peptoid "foldamers"--why the additional methylene unit?An update on lysine deacylases targeting the expanding "acylome".Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.Innovative Strategies for Selective Inhibition of Histone Deacetylases.Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: an investigation of N-alkylglycine (peptoid) rotamers.Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing SystemThe effect of various zinc binding groups on inhibition of histone deacetylases 1-11.Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides.Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.Cis-trans amide bond rotamers in β-peptoids and peptoids: evaluation of stereoelectronic effects in backbone and side chains.Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities.Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates.Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi.Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton ChannelRandom Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance MutantsHistone Deacetylase 11 Is an ε-N-Myristoyllysine HydrolaseAn NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFMTuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent BlockersAntiplasmodial and Prehemolytic Activities of α-Peptide–β-Peptoid ChimerasAntimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Christian A Olsen
@nl
Christian A Olsen
@sl
Christian A. Olsen
@en
Christian A. Olsen
@es
type
label
Christian A Olsen
@nl
Christian A Olsen
@sl
Christian A. Olsen
@en
Christian A. Olsen
@es
prefLabel
Christian A Olsen
@nl
Christian A Olsen
@sl
Christian A. Olsen
@en
Christian A. Olsen
@es
P106
P1153
7201889165
P31
P496
0000-0002-2953-8942