about
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNACrystal structure of peanut lectin, a protein with an unusual quaternary structureStructures of RNA polymerase-antibiotic complexesStructural basis of HIV-1 resistance to AZT by excisionThe RNA polymerase "switch region" is a target for inhibitorsTwo-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptaseLamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsX-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein foldStructural basis of BLyS receptor recognitionA Conserved Structural Module Regulates Transcriptional Responses to Diverse Stress Signals in BacteriaCrystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid LipofuscinosisCrystallographic Study of a Novel Subnanomolar Inhibitor Provides Insight on the Binding Interactions of Alkenyldiarylmethanes with Human Immunodeficiency Virus-1 Reverse TranscriptaseCrystal Structure of tert -Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding PocketCrystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease InhibitorsStructure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolutionCrystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutantStructures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistanceStructure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolutionA mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavirMolecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutationsPhenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.Structures of influenza A proteins and insights into antiviral drug targets.The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism.Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors.Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamerTrapping HIV-1 reverse transcriptase before and after translocation on DNA.Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures.The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro.Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.Negative-Strand RNA Virus L Proteins: One Machine, Many Activities.Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the dCrystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.Linear Interaction Energy (LIE) Models for Ligand Binding in Implicit Solvent: Theory and Application to the Binding of NNRTIs to HIV-1 Reverse Transcriptase.Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Kalyan Das
@ast
Kalyan Das
@en
Kalyan Das
@es
Kalyan Das
@nl
Kalyan Das
@sl
type
label
Kalyan Das
@ast
Kalyan Das
@en
Kalyan Das
@es
Kalyan Das
@nl
Kalyan Das
@sl
prefLabel
Kalyan Das
@ast
Kalyan Das
@en
Kalyan Das
@es
Kalyan Das
@nl
Kalyan Das
@sl
P106
P31
P496
0000-0002-8897-324X