about
Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome EditingDNA targeting specificity of RNA-guided Cas9 nucleasesTALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicityCRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequencesSeamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection.ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effectsCOSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target SitesEfficient fdCas9 Synthetic Endonuclease with Improved Specificity for Precise Genome EngineeringA Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood.Defining critical residues in the epitope for a HIV-neutralizing monoclonal antibody using phage display and peptide array technologies.Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human GenomeThe Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian CellsTALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activityNanomedicine: tiny particles and machines give huge gainsSAPTA: a new design tool for improving TALE nuclease activity.An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavageCodon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector.Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors.High-throughput cellular screening of engineered nuclease activity using the single-strand annealing assay and luciferase reporter.Designing and testing the activities of TAL effector nucleases.Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.Identification of off-target cleavage sites of zinc finger nucleases and TAL effector nucleases using predictive models.
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thomas J Cradick
@nl
Thomas J Cradick
@sl
Thomas J. Cradick
@en
Thomas J. Cradick
@es
type
label
Thomas J Cradick
@nl
Thomas J Cradick
@sl
Thomas J. Cradick
@en
Thomas J. Cradick
@es
prefLabel
Thomas J Cradick
@nl
Thomas J Cradick
@sl
Thomas J. Cradick
@en
Thomas J. Cradick
@es
P106
P1153
36907610800
P21
P31
P496
0000-0002-8489-8318