about
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targetsCellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in diseaseIn Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I MetabolitesDinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable ironThe Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling PathwaysTargeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.The role of NDRG1 in the pathology and potential treatment of human cancers.Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.Gene of the month: BECN1.Gene of the month. AMP kinase (PRKAA1).Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis.Adenosine monophosphate-activated kinase and its key role in catabolism: structure, regulation, biological activity, and pharmacological activation.The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia.Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.The mechanistic role of chemically diverse metal ions in the induction of autophagy.Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism.Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.Making a case for albumin – a highly promising drug-delivery system.Tumor stressors induce two mechanisms of intracellular p-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Sumit Sahni
@ast
Sumit Sahni
@en
Sumit Sahni
@es
Sumit Sahni
@nl
type
label
Sumit Sahni
@ast
Sumit Sahni
@en
Sumit Sahni
@es
Sumit Sahni
@nl
prefLabel
Sumit Sahni
@ast
Sumit Sahni
@en
Sumit Sahni
@es
Sumit Sahni
@nl
P106
P1153
52464404100
P31
P496
0000-0002-2900-8845