about
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesHigh-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonaseDiscovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reducesNimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia.Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Inhibitors of tissue-nonspecific alkaline phosphatase (TNAP): from hits to leads.Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell linesPathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoterDiabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis.SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation ComplexPPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine AbuseImidazole-derived agonists for the neurotensin 1 receptor.Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity.Arylmethylamino steroids as antiparasitic agents.Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling.Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptorCapzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5.Formation of vinyl halides via a ruthenium-catalyzed three-component coupling.A three-component coupling approach to cyclopentanoids.Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia.Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy.Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels SepsisRepurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularizationGlucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studiesDiaryl substituted pyrazoles as potent CCR2 receptor antagonistsAllosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Anthony B Pinkerton
@ast
Anthony B Pinkerton
@en
Anthony B Pinkerton
@es
Anthony B Pinkerton
@nl
type
label
Anthony B Pinkerton
@ast
Anthony B Pinkerton
@en
Anthony B Pinkerton
@es
Anthony B Pinkerton
@nl
prefLabel
Anthony B Pinkerton
@ast
Anthony B Pinkerton
@en
Anthony B Pinkerton
@es
Anthony B Pinkerton
@nl
P106
P1153
7006403240
P31
P496
0000-0003-4571-152X