about
Telomere dysfunction triggers developmentally regulated germ cell apoptosis.Haploinsufficiency of mTR results in defects in telomere elongation.Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere lengthAtaxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeresPhosphorylation of H2AX at short telomeres in T cells and fibroblasts.Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptaseShort telomeres are sufficient to cause the degenerative defects associated with agingBRD4 inhibitors block telomere elongation.Diagnostic utility of telomere length testing in a hospital-based setting.The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome StabilityTIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity
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description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Margaret A Strong
@ast
Margaret A Strong
@en
Margaret A Strong
@es
Margaret A Strong
@nl
type
label
Margaret A Strong
@ast
Margaret A Strong
@en
Margaret A Strong
@es
Margaret A Strong
@nl
prefLabel
Margaret A Strong
@ast
Margaret A Strong
@en
Margaret A Strong
@es
Margaret A Strong
@nl
P106
P1153
7101816632
P21
P31
P496
0000-0002-0055-6573