about
Prediction of drug-target interactions and drug repositioning via network-based inferenceSuppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCKIdentification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model.Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.HL005--a new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7.Luciferase reporter gene assay on human 5-HT receptor: which response element should be chosen?FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach.Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages.Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder.Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes.β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis.2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors.The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer.Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A.Natural products as a gold mine for selective matrix metalloproteinases inhibitors.Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity.Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation.Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives.Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors.2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies.The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.In silico prediction of chemical mechanism of action via an improved network-based inference method.Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo.Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway.Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.Development of a new colorimetric assay for lipoxygenase activity.Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity.Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibit Plasmodium Falciparum Dihydroorotate Dehydrogenase.Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screeningDiscovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screeningStructure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid ChannelSelective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent modelsDesign, synthesis, and biological evaluations of phenylpropiolic acid derivatives as novel GPR40 agonistsDiscovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy
P50
Q28483634-25742BFD-2A88-486A-8689-1D09A6270794Q28833740-3276C4FE-97A9-4449-8DA4-11C5EBA79704Q31034275-9BB7A49E-E179-4B2D-93B3-62ACAEB28A3CQ33479694-50360AC4-7ECF-48C9-A157-F051118F8E51Q33812433-ECDA9BBB-68DF-4A00-BD98-8A72696D2EDDQ35015287-3F37AF57-07C9-4EA0-80C8-9A6B9C0457C7Q35025312-EACD3D78-F840-4E0C-84A7-3A400DB38FF2Q37209835-D6225E0D-E681-4424-B91A-99CFDD5C670EQ37564392-646B69C3-F88D-4152-B063-4CA2F4C3F941Q37575496-37CC968E-A6E9-4D20-8BDB-7D74E605472CQ38780512-A03CD406-D2FE-45AE-B4EC-4082E5817B3FQ38824844-221E6329-052A-4314-9900-3A032E201A4EQ38944223-95A28E68-B777-42B9-A80F-EE00CE7C9BC9Q38964447-3E8B2E9A-5C14-414E-A715-C9E4F855B97DQ39338417-BC7AED68-0BE2-4025-9925-57BAE5F04BA8Q39478463-96A76878-EDDE-4A03-9BFE-D6C7F10B04E7Q39559438-E1A31DC3-442B-4667-B64D-64FD5FB3C44AQ39631904-E754B402-82B9-4093-9B46-2626BC393D88Q39646093-CE186387-5476-4207-9F2E-578547AB63DCQ39672806-F96A730E-1656-4392-AFBD-E7A8FF6332E0Q40001873-7398AFC9-623E-476F-9D4D-19E50AE592E3Q42230992-C321F4B2-8D34-4DD9-BF07-8EC4BA7E5463Q42733212-EDEA7D81-D5D8-410D-9CF8-1EF59085713CQ45360189-66B221DD-C1B1-4F2E-9863-C456B36207F7Q46153985-51A85334-5B9D-4017-9204-FC7B11814796Q46860326-56BB373C-13E2-4272-A96F-EC3078EA49B2Q47168067-E7F1A769-7C4A-45A8-8CCF-DEAEE35BA702Q47407582-692383AC-2C87-47A5-AC82-30AE781251B7Q48021721-2AA89A02-B2EC-4EF4-824E-6D48B4FB592EQ48194709-01C5C499-910B-4229-B221-3D574FAA4B1DQ48217763-29A68E08-7936-410E-A682-8C560009D6DDQ50489114-0CC290F9-49A5-4091-BFC4-3192961690DCQ51048900-730AE72A-8820-41B3-B7FA-8BEA87ECEB42Q52628642-D2532264-D7A2-45C1-9CBF-EF2657B55174Q84979910-0D49F042-471A-4C4E-A2DF-093EF3BA83C2Q86761690-61F5A452-5324-42B6-8AEC-88458A919CE4Q90940652-6DB798EE-456E-48DE-AD24-94828EE3C733Q91360551-DE04A117-2779-4F3C-B57B-0042CB82407FQ91429571-73416DDC-4DA8-4564-BD4F-59A4FACF346EQ92119312-4DBA90D5-F345-4F65-978C-48AF472B25DF
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Weiqiang Lu
@ast
Weiqiang Lu
@en
Weiqiang Lu
@es
Weiqiang Lu
@nl
type
label
Weiqiang Lu
@ast
Weiqiang Lu
@en
Weiqiang Lu
@es
Weiqiang Lu
@nl
prefLabel
Weiqiang Lu
@ast
Weiqiang Lu
@en
Weiqiang Lu
@es
Weiqiang Lu
@nl
P106
P31
P496
0000-0003-1349-6597