about
Human isoprenoid synthase enzymes as therapeutic targetsCrystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaoseSubstrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily membersStructural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyaseStructural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-bStructural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiaeCrystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactorStructural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside AntibioticsMultiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate ResistanceStructure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophilaCrystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase InhibitorCrystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinasesTernary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closureNovel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structureStructural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35AStructural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside KinasesDesign and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cellsThe Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like ConformationStructure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphateThienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibitionMultistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseasesMaintenance of native-like protein dynamics may not be required for engineering functional proteinsLactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysisProbing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthaseStructural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside DesignAntibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-IaThe role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome cMutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environmentExpression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity.Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutationMechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loopMagnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases.Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpOProtein tyrosine phosphatases are regulated by mononuclear iron dicitrate.New phenolic inhibitors of yeast homoserine dehydrogenase.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity.Protein kinase inhibitors and antibiotic resistance.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Albert M Berghuis
@ast
Albert M Berghuis
@en
Albert M Berghuis
@es
Albert M Berghuis
@nl
type
label
Albert M Berghuis
@ast
Albert M Berghuis
@en
Albert M Berghuis
@es
Albert M Berghuis
@nl
prefLabel
Albert M Berghuis
@ast
Albert M Berghuis
@en
Albert M Berghuis
@es
Albert M Berghuis
@nl
P106
P21
P31
P496
0000-0002-2663-025X