about
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse modelTargeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemiaThe Index-based Subgraph Matching Algorithm with General Symmetries (ISMAGS): exploiting symmetry for faster subgraph enumerationRNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications.Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemiaMutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing.Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.BCR-ABL1 positive B-ALL can undergo T-cell lineage shift to become CD19 negative T-ALLSafe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibitionSuz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Sofie Demeyer
@ast
Sofie Demeyer
@en
Sofie Demeyer
@es
Sofie Demeyer
@nl
type
label
Sofie Demeyer
@ast
Sofie Demeyer
@en
Sofie Demeyer
@es
Sofie Demeyer
@nl
prefLabel
Sofie Demeyer
@ast
Sofie Demeyer
@en
Sofie Demeyer
@es
Sofie Demeyer
@nl
P106
P1153
56425909700
P21
P31
P496
0000-0002-8193-5734