Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

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2017 nî lūn-bûn

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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P1476

Mutant JAK3 signaling is incre ...... ndary JAK3 mutations in T-ALL.

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P2093

Christine J Harrison

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Ellen Geerdens

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Emilie Leroy

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Jean Soulier

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Kris Jacobs

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Olga Gielen

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Simon Bornschein

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Stefan N Constantinescu

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P2860

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities.

JAK and STAT signaling molecules in immunoregulation and immune-mediated disease.

P304

421-425

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scholarly article

P356

10.1182/BLOOD-2017-07-797597

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English

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P478

131

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P577

2017-11-29T00:00:00Z

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P698

29187379

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P932

5796683

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