about
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responsesIncreased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liverVitamin E is essential for mouse placentation but not for embryonic development itselfSNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary DisordersRegulation of macrophage function in inflammation and atherosclerosis25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth.Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinaseDeubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cellsRational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residuesDevelopment of a Potent Protein Degrader against Oncogenic BCR-ABL ProteinTargeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERsSNIPERs-Hijacking IAP activity to induce protein degradation
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Norihito Shibata
@ast
Norihito Shibata
@en
Norihito Shibata
@es
Norihito Shibata
@nl
type
label
Norihito Shibata
@ast
Norihito Shibata
@en
Norihito Shibata
@es
Norihito Shibata
@nl
prefLabel
Norihito Shibata
@ast
Norihito Shibata
@en
Norihito Shibata
@es
Norihito Shibata
@nl
P106
P31
P496
0000-0001-5792-8510