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Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational SelectionCrystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin InhibitorsCrystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug designStructures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase InhibitorsMetalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction SitesComparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.From snake venom toxins to therapeutics--cardiovascular examples.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.Noncompetitive inhibitor of thrombin.X-ray crystallographic analysis of time-dependent binding of guanidine hydrochloride to HEWL: First steps during protein unfoldingAnticoagulants from hematophagous animalsToxins Are an Excellent Source of Therapeutic Agents against Cardiovascular DiseasesNatriuretic peptide analogues with distinct vasodilatory or renal activity: Integrated effects in health and experimental heart failureOmics Technologies for Profiling Toxin Diversity and Evolution in Snake Venom: Impacts on the Discovery of Therapeutic and Diagnostic AgentsThe First Intrinsic Tenase Complex Inhibitor with Serine Protease Structure Offers a New Perspective in Anticoagulant TherapyExogenous Factors from Venomous and Hematophagous Animals in Drugs and Diagnostic Developments for Cardiovascular and Neurovascular DiseasesRepurposed drug to the rescue of snakebite victimsThe Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Cho Yeow Koh
@ast
Cho Yeow Koh
@en
Cho Yeow Koh
@es
Cho Yeow Koh
@nl
type
label
Cho Yeow Koh
@ast
Cho Yeow Koh
@en
Cho Yeow Koh
@es
Cho Yeow Koh
@nl
prefLabel
Cho Yeow Koh
@ast
Cho Yeow Koh
@en
Cho Yeow Koh
@es
Cho Yeow Koh
@nl
P106
P1153
35310733300
P31
P496
0000-0003-0002-4603