Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

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http://www.wikidata.org/entity/Q27683462
Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase InhibitorsThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsBrucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for BrucellosisThe "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections.Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis.Novel lead compounds in pre-clinical development against African sleeping sickness
P2860

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

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http://www.wikidata.org/entity/Q27683462
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2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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Structures of Trypanosoma bruc ...... sign against sleeping sickness
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10.1371/JOURNAL.PNTD.0002775
P407
P433
P478
P50
P577
P5875
P698
P921
P932