Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice
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Molecular mechanisms of autoimmunity triggered by microbial infection.Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic interventionSuppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis.Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in miceTherapeutic strategies for SLE involving cytokines: mechanism-oriented therapies especially IFN-gamma targeting gene therapy.Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice.Mammalian telomeric DNA suppresses endotoxin-induced uveitisToll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation.Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 bindingEffect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomasPainful pathways induced by TLR stimulation of dorsal root ganglion neuronsPre-clinical screening of immunomodulatory compounds using the parent-into-F1 model.β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats.Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onsetProgress in drug development of immunostimulatory CpG oligodeoxynucleotide ligands for TLR9.Autoantibodies make a U-turn: the toll hypothesis for autoantibody specificity.Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusImmune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.Microbial nucleic acids pay a Toll in kidney disease.TLR9 in health and disease.Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsDesign, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.Synthetic oligonucleotides as modulators of inflammationToll-like receptors as therapeutic targets for autoimmune connective tissue diseasesSuppressive oligodeoxynucleotides promote the development of Th17 cells.Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity.Developments in the scientific understanding of lupus.Use of nanoparticles to deliver immunomodulatory oligonucleotides.Targeting of the immune system in systemic lupus erythematosus.DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivoSuppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury.Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.
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Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice
description
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2005
@uk
name
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@en
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@nl
type
label
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@en
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@nl
prefLabel
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@en
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@nl
P2093
P2860
P921
P356
P1476
Suppressive oligodeoxynucleoti ...... in lupus-prone NZB × NZW mice
@en
P2093
Dennis M. Klinman
Shuichi Ito
P2860
P304
P356
10.1002/ART.20810
P50
P577
2005-02-01T00:00:00Z