The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
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ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cellsConstitutive and inducible expression of b7 family of ligands by human airway epithelial cellsThe costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsT cell activationLigand binding sites of inducible costimulator and high avidity mutants with improved functionFollicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionEmerging mechanisms of immune regulation: the extended B7 family and regulatory T cellsInhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia.ICOS Co-Stimulation: Friend or Foe?VSIG4, a B7 family-related protein, is a negative regulator of T cell activationThe junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activationA single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinaseAntigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner.T cell immune abnormalities in immune thrombocytopenia.Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cellsInduction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studiesB7h is required for T cell activation, differentiation, and effector function.Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine ModelYin-Yang of costimulation: crucial controls of immune tolerance and function.Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection.Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune miceFollicular homing T helper (Th) cells and the Th1/Th2 paradigm.B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women.Costimulatory pathways in transplantation.B7h-expressing dendritic cells and plasma B cells mediate distinct outcomes of ICOS costimulation in T cell-dependent antibody responses.Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMPActivation and inhibition of lymphocytes by costimulation.Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signalingDifferences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4Interplay between T helper type 1 and type 2 cytokines and soluble major histocompatibility complex molecules: a paradigm in pregnancy.Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in miceDisruption of the ICOS-B7RP-1 costimulatory pathway leads to enhanced hepatic immunopathology and increased gamma interferon production by CD4 T cells in murine schistosomiasis.ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62LB7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responsesInhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac graftsT-cell activation and transplantation tolerance.
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The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
description
article
@en
im Juli 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2000
@uk
name
The CD28-related molecule ICOS ...... ell-dependent immune responses
@en
The CD28-related molecule ICOS ...... ell-dependent immune responses
@nl
type
label
The CD28-related molecule ICOS ...... ell-dependent immune responses
@en
The CD28-related molecule ICOS ...... ell-dependent immune responses
@nl
prefLabel
The CD28-related molecule ICOS ...... ell-dependent immune responses
@en
The CD28-related molecule ICOS ...... ell-dependent immune responses
@nl
P2093
P1433
P1476
The CD28-related molecule ICOS ...... ell-dependent immune responses
@en
P2093
H Schneider
J A Gonzalo
J C Gutierrez-Ramos
M Gosselin
P304
P356
10.1016/S1074-7613(00)00011-X
P407
P577
2000-07-01T00:00:00Z