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Activation and allosteric modulation of a muscarinic acetylcholine receptorEndogenous allosteric modulators of G protein-coupled receptors3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonistsMolecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorProbing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004.Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonistPositive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.Label-Free Kinetics: Exploiting Functional Hemi-Equilibrium to Derive Rate Constants for Muscarinic Receptor Antagonists.Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor.Allosteric modulation of endogenous metabolites as an avenue for drug discovery.Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.Allosteric functional switch of neurokinin A-mediated signaling at the neurokinin NK2 receptor: structural exploration
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Celine Valant
@ast
Celine Valant
@en
Celine Valant
@es
Celine Valant
@nl
type
label
Celine Valant
@ast
Celine Valant
@en
Celine Valant
@es
Celine Valant
@nl
prefLabel
Celine Valant
@ast
Celine Valant
@en
Celine Valant
@es
Celine Valant
@nl
P106
P1153
25226064800
P31
P496
0000-0002-2509-7465