Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation
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Secondary peripheral chondrosarcoma evolving from osteochondroma as a result of outgrowth of cells with functional EXTUnsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.HSPG-deficient zebrafish uncovers dental aspect of multiple osteochondromas.Glycobiology and the growth plate: current concepts in multiple hereditary exostosesNFAT restricts osteochondroma formation from entheseal progenitorsEpiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter.Cell biology of osteochondromas: bone morphogenic protein signalling and heparan sulphates.Hereditary Multiple Exostoses: New Insights into Pathogenesis, Clinical Complications, and Potential Treatments.Assessing the general population frequency of rare coding variants in the EXT1 and EXT2 genes previously implicated in hereditary multiple exostosesEpiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage.The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses.Biology of Bone Sarcomas and New Therapeutic Developments.Malignant degeneration of a lumbar osteochondroma into a chondrosarcoma which mimicked a large retropertioneal mass.
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P2860
Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation
description
article
@en
im Juli 2010 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2010
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name
Genetic models of osteochondro ...... tive to EXT genes inactivation
@en
Genetic models of osteochondro ...... tive to EXT genes inactivation
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type
label
Genetic models of osteochondro ...... tive to EXT genes inactivation
@en
Genetic models of osteochondro ...... tive to EXT genes inactivation
@nl
prefLabel
Genetic models of osteochondro ...... tive to EXT genes inactivation
@en
Genetic models of osteochondro ...... tive to EXT genes inactivation
@nl
P2093
P2860
P356
P1433
P1476
Genetic models of osteochondro ...... tive to EXT genes inactivation
@en
P2093
F Sgariglia
F V Gentile
L Sangiorgi
M Alberghini
M Pandolfi
P2860
P2888
P304
P356
10.1038/ONC.2010.135
P407
P577
2010-07-01T00:00:00Z