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Structural basis for complement factor H linked age-related macular degenerationGenetic variants in the complement system predisposing to age-related macular degeneration: a reviewAssociative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparinShiga toxin activates complement and binds factor H: evidence for an active role of complement in hemolytic uremic syndromeImpaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Age and Smoking Related Changes in Metal Ion Levels in Human Lens: Implications for Cataract FormationDevelopment of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions.Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.Age-related macular degeneration: genome-wide association studies to translation.Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.The proteoglycan glycomatrix: a sugar microenvironment essential for complement regulation.The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement RegulationAge-related macular degeneration and the role of the complement system.Complement factor H in host defense and immune evasion.The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.Enrichment of Bruch's Membrane from Human Donor EyesRole of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation.The eye as a complement dysregulation hotspot.Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration.Induction of Chemokine Secretion and Monocyte Migration by Human Choroidal Melanocytes in Response to Proinflammatory Cytokines.His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated FormWhole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genesIncreased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degenerationLoss-of-Function Mutations in the CFH Gene Affecting Alternatively Encoded Factor H-like 1 Protein Cause Dominant Early-Onset Macular Drusen
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description
researcher
@en
wetenschapper
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հետազոտող
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name
Simon J Clark
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Simon J Clark
@en
Simon J Clark
@es
Simon J Clark
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type
label
Simon J Clark
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Simon J Clark
@en
Simon J Clark
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Simon J Clark
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prefLabel
Simon J Clark
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Simon J Clark
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Simon J Clark
@es
Simon J Clark
@nl
P106
P31
P496
0000-0001-8394-8355