His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form
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Bivalent and co-operative binding of complement factor H to heparan sulfate and heparinAnnexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cellsStructural basis for complement factor H linked age-related macular degenerationThe complotype: dictating risk for inflammation and infectionGenetic variants in the complement system predisposing to age-related macular degeneration: a reviewMüller glia activation in response to inherited retinal degeneration is highly varied and disease-specificStructure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphismThe Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan InteractionsTSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8Systemic complement activation in age-related macular degenerationComplement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Complement factor H: using atomic resolution structure to illuminate disease mechanisms.Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degenerationAssociation of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.The Immune System and AMDComplement control protein factor H: the good, the bad, and the inadequate.Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Immobilization of heparan sulfate on electrospun meshes to support embryonic stem cell culture and differentiation.The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical applicationZinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration.Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularizationAdvanced glycation endproduct changes to Bruch's membrane promotes lipoprotein retention by lipoprotein lipaseAnalysis of rare variants in the CFH gene in patients with the cuticular drusen subtype of age-related macular degenerationMapping the differential distribution of glycosaminoglycans in the adult human retina, choroid, and sclera.Regulation of age-related macular degeneration-like pathology by complement factor H.Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid.Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions.Complement Dysregulation and Disease: Insights from Contemporary Genetics.Complement activation, regulation, and molecular basis for complement-related diseasesAge-related macular degeneration: genome-wide association studies to translation.Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.Role of heparan sulfate in ocular diseases.Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration.The role of the immune response in age-related macular degenerationTranslational mini-review series on complement factor H: structural and functional correlations for factor H.Anticomplement therapy.Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.
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P2860
His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juni 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 2006
@uk
name
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@en
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@nl
type
label
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@en
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@nl
prefLabel
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@en
His-384 Allotypic Variant of F ...... he Non-disease-associated Form
@nl
P2860
P50
P356
P1476
His-384 allotypic variant of f ...... he non-disease-associated form
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P2093
Barbara Mulloy
Stephen J Perkins
P2860
P304
24713-24720
P356
10.1074/JBC.M605083200
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P577
2006-06-20T00:00:00Z