about
Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistanceFacilitating Akt clearance via manipulation of Hsp70 activity and levels.The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.Human cyclophilin 40 unravels neurotoxic amyloids.Hsc70 rapidly engages tau after microtubule destabilizationHeat shock protein 90 inhibitors in the treatment of cancer: current status and future directionsPhosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy.Stressing Out Hsp90 in Neurotoxic Proteinopathies.Chaperone signalling complexes in Alzheimer's disease.Neuronal life span versus health span: principles of natural selection at work in the degenerating brain.Hsp90 activator Aha1 drives production of pathological tau aggregates.The epichaperome is an integrated chaperome network that facilitates tumour survivalRNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.Chemical manipulation of hsp70 ATPase activity regulates tau stability.Reconstructing the Hsp90/Tau Machine.Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention.Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.Hsp90 and FKBP51: complex regulators of psychiatric diseases.Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSDThe epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
John Koren
@ast
John Koren
@en
John Koren
@es
John Koren
@nl
type
label
John Koren
@ast
John Koren
@en
John Koren
@es
John Koren
@nl
prefLabel
John Koren
@ast
John Koren
@en
John Koren
@es
John Koren
@nl
P106
P1153
16060874900
P31
P496
0000-0002-6017-1763