about
Pushing the size limit of de novo structure ensemble prediction guided by sparse SDSL-EPR restraints to 200 residues: The monomeric and homodimeric forms of BAXPhosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion.Dynamic interaction of cBid with detergents, liposomes and mitochondria.New biophysical methods to study the membrane activity of Bcl-2 proteins.Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric speciesConformational changes and protein stability of the pro-apoptotic protein Bax.Automated analysis of giant unilamellar vesicles using circular Hough transformation.Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces.cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size.Structural model of active Bax at the membrane.Molecular details of Bax activation, oligomerization, and membrane insertion.Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.New limits of sensitivity of site-directed spin labeling electron paramagnetic resonance for membrane proteins.The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.Bcl-2 proteins: Unraveling the details of a complex and dynamic network.A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labelsTopology of active, membrane-embedded Bax in the context of a toroidal poregem-Diethyl Pyrroline Nitroxide Spin Labels: Synthesis, EPR Characterization, Rotamer Libraries and Biocompatibility
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Stephanie Bleicken
@ast
Stephanie Bleicken
@en
Stephanie Bleicken
@es
Stephanie Bleicken
@nl
type
label
Stephanie Bleicken
@ast
Stephanie Bleicken
@en
Stephanie Bleicken
@es
Stephanie Bleicken
@nl
prefLabel
Stephanie Bleicken
@ast
Stephanie Bleicken
@en
Stephanie Bleicken
@es
Stephanie Bleicken
@nl
P214
P106
P214
P31
P496
0000-0002-4789-0974
P7859
viaf-89877406