Molecular details of Bax activation, oligomerization, and membrane insertion. - Wikidata - awgldk - TriplyDB

Molecular details of Bax activation, oligomerization, and membrane insertion.

Molecular details of Bax activation, oligomerization, and membrane insertion.

http://www.wikidata.org/entity/Q42910802

about

Heterodimerization of BAK and MCL-1 activated by detergent micelles Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore The targeting of plasmalemmal ceramide to mitochondria during apoptosis Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes Pro-apoptotic Bax molecules densely populate the edges of membrane pores.Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane.The rheostat in the membrane: BCL-2 family proteins and apoptosis Dynamic interaction of cBid with detergents, liposomes and mitochondria.Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes.Apoptotic cell signaling in cancer progression and therapy Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.Bax forms two types of channels, one of which is voltage-gated Identification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neurons Mitochondria and apoptosis: emerging concepts.Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.Bax dimerizes via a symmetric BH3:groove interface during apoptosis Ceramide channels: destabilization by Bcl-xL and role in apoptosis Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species The dynamics of Bax channel formation: influence of ionic strength BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes Leishmania donovani Exploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis.Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.Mechanisms of action of Bcl-2 family proteins Sensitive Cu2+-Cu2+ distance measurements in a protein-DNA complex by double-quantum coherence ESR.In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy.A common landscape for membrane-active peptides.Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane.Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis.Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis.After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.The secrets of the Bcl-2 family.Apoptosis regulation at the mitochondrial outer membrane.

P2860

Q24305060-6F258DC6-941D-49AD-8296-0F173A671FF6 Q26750639-E481F118-C5BC-4F44-9A04-955690808301 Q27002044-8DA243E1-C177-46A1-BAA6-4DA73DF97C16 Q27323504-CB5B19E5-E7BD-4AFD-AA54-955A41EA6AEE Q28300914-F3803D91-DDE2-4AB0-A364-6B80A05DB16D Q28483986-67E04F02-141A-4A30-9F5D-E01EE79BE29A Q30388868-AE091BBE-3452-4E02-9586-35BF62278272 Q33361524-EDAE30A4-1558-4914-9937-37A87C1B41BE Q33640395-4450B1DF-B209-4C85-9B1C-6F593297363C Q33752784-9C5E8876-BEF2-4B50-8AF8-CAD2BC36CA57 Q34038716-36E4E611-6987-4D79-94D3-7806A40DAC79 Q34249427-3E512E38-DA9E-4F33-9555-4EE0B2CF64E9 Q34314503-CDC50365-ED95-4C16-ADA5-CA7DEFE43DF3 Q34486441-CFD0CBE1-17D4-49C3-8A49-5A4318C239BD Q34552749-A740F4AC-9091-4B2F-977F-4B1E0BDA9D16 Q34654834-CBD70A91-DE8D-4D32-8350-46304EF69FE6 Q34960771-7C8BF948-542C-44C3-8362-84A2E93FCC61 Q35088734-0CD264E4-673E-49D1-8204-7F64499CA3F4 Q35165455-F0FF6B0C-7422-48C1-A5EB-E74A9BEB20B8 Q35512551-DAFDEC05-A0F3-451F-A8AA-F3F684900306 Q35552682-3AFB2E8F-94CB-4245-BB92-800CDE15CF43 Q35659301-9487FB5A-ACAF-4A1C-89FB-6211BE480706 Q35839831-8168817D-5663-4911-ACB8-A2B170727BEA Q35840528-BE949F32-DEC7-4B20-8257-C7B2D7312491 Q36011641-00527C3B-69D1-495C-8848-A471564CE4D5 Q36018810-872FA6C2-EDAD-4425-8151-B470C520C9FC Q36150746-9105F5D3-90C2-4A39-A34F-88BB7571CB97 Q36478810-1A189F9D-E780-41FC-AB97-1B510D652CC9 Q36574003-83AB6727-C74F-4E76-BCED-58EA8657029D Q36629743-F72EA94B-5DE9-420E-AD2D-032494C3506A Q36932838-FB2C65CE-A234-44E7-89F4-7C2F69E70C93 Q36936967-2E59D4AB-0508-4E19-AA4D-4148AAAA44C9 Q36996518-0978B3A1-95F8-45DF-9A2C-05251D5DAB72 Q37034573-FA2FA6FF-40E2-4F41-BD96-719812B349CE Q37257680-57B5CF87-A3FA-465C-B335-274CB1753692 Q37465922-AC8079EB-5215-4A92-A1DB-2DDB94C4B6EA Q37713569-209F6C28-7EC3-466F-BCD1-EFDC84E9F333 Q37727610-E0A3D4C0-32E8-4052-AD59-FC47E0CF9CBB Q38039293-C8872467-F773-49DF-9AC9-350ED8E9ABC7 Q38181031-A1141C64-8241-4CD5-AC60-16ACEF7176A8

P2860

Molecular details of Bax activation, oligomerization, and membrane insertion.

http://www.wikidata.org/entity/Q42910802

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

2009年论文

@zh

2009年论文

@zh-cn

name

Molecular details of Bax activation, oligomerization, and membrane insertion.

@en

Molecular details of Bax activation, oligomerization, and membrane insertion.

@nl

type

label

Molecular details of Bax activation, oligomerization, and membrane insertion.

@en

Molecular details of Bax activation, oligomerization, and membrane insertion.

@nl

prefLabel

Molecular details of Bax activation, oligomerization, and membrane insertion.

@en

Molecular details of Bax activation, oligomerization, and membrane insertion.

@nl

P1433

Q42910802-A8AD5D77-A725-431B-9FF9-383402EC82C3

P1476

Q42910802-1D2F77AC-891A-4E47-8EE0-36E3E430B5AD

P2093

Q42910802-04A357F3-68BE-493F-82B4-BA32E3C679AC

Q42910802-1EC03042-0DE7-45E0-B907-0CC288BA7829

Q42910802-A570E7A7-6403-49F5-8181-2F7F5B21D038

Q42910802-F398ED67-DFDE-48FF-B32B-DCAB0DC181FF

P2860

Q42910802-04A697F0-73A4-4C14-AC2E-35654A5BFB8C

Q42910802-0911FFBE-7609-41DC-86ED-157A7B86D723

Q42910802-0C396ECC-AC37-4B86-B2AB-114FE68CDCAB

Q42910802-0C71C5FF-1187-4B24-81AB-E475790F57F4

Q42910802-0FF0C559-2D33-42D3-881E-90CD0FA407AB

Q42910802-1092A166-DD11-4555-9CA2-364D525E64BF

Q42910802-131C955C-39EC-46C2-85F0-DBB6CD358F7C

Q42910802-27BDB430-6D3A-4D6D-B524-DCFF2BE49FED

Q42910802-2CC6F677-498A-4DB3-BEE5-4AAFB1F7A8B9

Q42910802-36A8018C-CDAF-4EA1-8CB2-D17973B08B75

P304

Q42910802-A20F1445-1A17-42CA-9E5B-2D446BB3F982

P31

Q42910802-367CE150-7F0B-4958-B47A-1AC18F8ABED0

P356

Q42910802-58B91F76-5CEB-4A29-BB6B-F49E2B88547F

P407

Q42910802-C86603B0-D030-472B-9D95-8A561A8492AA

P433

Q42910802-CA2B202C-7194-4E21-9E65-39EEE5A16588

P478

Q42910802-0B937232-D207-4995-AA54-5F60517A853A

P50

Q42910802-2A2B1797-FA63-45A5-B11C-F40E3FBE19CD

Q42910802-656C1D71-4AF1-459D-91D1-F10F4076FC18

Q42910802-A5FDEF32-4534-43AC-B9BA-838EC7CC4F10

P577

Q42910802-C37B92A2-504E-481F-B345-03C97EA3F540

P5875

Q42910802-C54F5368-8E2A-47DD-A09E-95CF4FB9668B

P698

Q42910802-C355523B-7895-41BA-9B55-C585E930E6A0

P932

Q42910802-DFBB677C-3394-4498-B196-06D587815AC3

P356

JBC.M109.081539

P1433

Journal of Biological Chemistry

P1476

Molecular details of Bax activation, oligomerization, and membrane insertion

@en

P2093

Enrica Bordignon

http://www.w3.org/2001/XMLSchema#string

Kornelius Zeth

http://www.w3.org/2001/XMLSchema#string

Mirjam Classen

http://www.w3.org/2001/XMLSchema#string

Pulagam V L Padmavathi

http://www.w3.org/2001/XMLSchema#string

P2860

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

Conformation of the Bax C-terminus regulates subcellular location and cell death

Movement of Bax from the cytosol to mitochondria during apoptosis

A simple method for displaying the hydropathic character of a protein

Solution structure of BID, an intracellular amplifier of apoptotic signaling

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

P304

6636-6647

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M109.081539

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

285

http://www.w3.org/2001/XMLSchema#string

P50

Takashi Ishikawa

Stephanie Bleicken

Heinz-Jürgen Steinhoff

P577

2009-12-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40686089

http://www.w3.org/2001/XMLSchema#string

P698

20008353

http://www.w3.org/2001/XMLSchema#string

P932

2825459

http://www.w3.org/2001/XMLSchema#string