Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains
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MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding proteinDirect regulation of CREB transcriptional activity by ATM in response to genotoxic stressSolution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulationStructural Basis for Ubiquitin Recognition by SH3 DomainsConserved Themes in Target Recognition by the PAH1 and PAH2 Domains of the Sin3 Transcriptional CorepressorSolution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognitionRoles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activatorsCooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domainIdentification of small-molecule antagonists that inhibit an activator: coactivator interaction.Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB.Prepaying the entropic cost for allosteric regulation in KIXMolecular recognition by the KIX domain and its role in gene regulation.HTLV-1 HBZ protein deregulates interactions between cellular factors and the KIX domain of p300/CBP.Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes.Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300.A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta geneOPUS-Dom: applying the folding-based method VECFOLD to determine protein domain boundaries.Transcriptional switches: chemical approaches to gene regulationMacromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination.Mutational analysis of the KIX domain of CBP reveals residues critical for SREBP binding.Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells.FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.Amphipathic small molecules mimic the binding mode and function of endogenous transcription factorsTranscriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators.Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.Molecular Basis for the Mechanism of Constitutive CBP/p300 Coactivator Recruitment by CRTC1-MAML2 and Its Implications in cAMP Signaling.Dioxin-inducible transactivation in a chromosomal setting. Analysis of the acidic domain of the Ah receptor.Targeting Unoccupied Surfaces on Protein-Protein Interfaces.Functional silencing of TATA-binding protein (TBP) by a covalent linkage of the N-terminal domain of TBP-associated factor 1.
P2860
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P2860
Structural analyses of CREB-CBP transcriptional activator-coactivator complexes by NMR spectroscopy: implications for mapping the boundaries of structural domains
description
im April 1999 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у квітні 1999
@uk
name
Structural analyses of CREB-CB ...... undaries of structural domains
@en
Structural analyses of CREB-CB ...... undaries of structural domains
@nl
type
label
Structural analyses of CREB-CB ...... undaries of structural domains
@en
Structural analyses of CREB-CB ...... undaries of structural domains
@nl
prefLabel
Structural analyses of CREB-CB ...... undaries of structural domains
@en
Structural analyses of CREB-CB ...... undaries of structural domains
@nl
P2093
P356
P1476
Structural analyses of CREB-CB ...... undaries of structural domains
@en
P2093
David Parker
Gabriela C Pérez-Alvarado
H.Jane Dyson
Ishwar Radhakrishnan
Marc R Montminy
P304
P356
10.1006/JMBI.1999.2658
P407
P50
P577
1999-04-01T00:00:00Z