about
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membraneBax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic functionIdentification of an activation site in Bak and mitochondrial Bax triggered by antibodies.Disordered clusters of Bak dimers rupture mitochondria during apoptosis.Pore formation by dimeric Bak and Bax: an unusual pore?Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitationRobust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
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description
researcher
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wetenschapper
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հետազոտող
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name
Sweta Iyer
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Sweta Iyer
@en
Sweta Iyer
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Sweta Iyer
@nl
type
label
Sweta Iyer
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Sweta Iyer
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Sweta Iyer
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Sweta Iyer
@nl
prefLabel
Sweta Iyer
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Sweta Iyer
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Sweta Iyer
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Sweta Iyer
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P106
P31
P496
0000-0002-7787-5118