about
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activityp62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogrammingNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcriptionNrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemiaThe distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesisGenetic analysis of cytoprotective functions supported by graded expression of Keap1Molecular basis of the Keap1-Nrf2 system.Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels.Keap1 inhibition attenuates glomerulosclerosis.Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus.Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish.The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2.The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin.Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo.Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesisMolecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Takafumi Suzuki
@ast
Takafumi Suzuki
@en
Takafumi Suzuki
@es
Takafumi Suzuki
@nl
type
label
Takafumi Suzuki
@ast
Takafumi Suzuki
@en
Takafumi Suzuki
@es
Takafumi Suzuki
@nl
prefLabel
Takafumi Suzuki
@ast
Takafumi Suzuki
@en
Takafumi Suzuki
@es
Takafumi Suzuki
@nl
P106
P1153
55731637800
P31
P496
0000-0002-3425-8208